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Intraosseous Injections: Treating Pain From Inside the Bone

Orthopedic bone injections in Fort Lauderdale with Dr. Jorge A. Gonzalez, MD, triple board-certified

An intraosseous (IO) injection places medicine or a treatment directly inside a bone. “Intraosseous” simply means “inside the bone.”

At the Institute of Regenerative Orthopedics & Sports Medicine (IROSM), Dr. Jorge Gonzalez, MD at IROSM in Fort Lauderdale uses intraosseous injections for some cases of severe knee arthritis, bone swelling and slow-healing fractures, when the problem sits in the bone under the joint. In the video, he explains options for a fracture that has not healed.

Book Your Appointment Now: (954) 751-6990 Make an Inquiry Online
Non-Surgical Options for a Non-Healing Fracture | Fort Lauderdale | Dr. Jorge Gonzalez, IROSM
Important Notice from IROSM: Intraosseous injections are not right for every patient. After an exam and a review of your MRI at IROSM in Fort Lauderdale, Dr. Jorge Gonzalez will tell you whether a bone injection fits your problem, or whether another option, including surgery, is the better choice.

Two Kinds of Intraosseous (IO) Injections

The term “IO injection” is used in two very different settings:

Emergency IO Access

In an emergency, when a vein cannot be found, paramedics and hospital teams place a needle into a bone, often the shin, to give fluids and medicines quickly. This is a life-saving step, not a treatment for pain.

Orthopedic IO Injection

In orthopedics, a doctor places a treatment into a painful area of bone, most often just under the knee joint surface, to treat the bone itself. This is what IROSM offers.

Why Treat the Bone?

In a joint like the knee, the smooth cartilage sits on a layer of bone called the subchondral bone. In more advanced arthritis, this bone can become swollen and damaged. On an MRI, this shows up as a bone marrow lesion or bone swelling (edema), and it is often linked to more pain.

A standard joint injection reaches the space inside the joint, but not the bone underneath. An intraosseous injection is designed to reach that bone directly.

Conditions Where a Bone Injection May Be Considered

Many of these patients are in what doctors call the treatment gap: simple care has not helped enough, but they are not ready for surgery, or surgery is not a good fit for them.

What Happens During an Intraosseous Injection

1. Planning

Dr. Gonzalez reviews your MRI to find the exact area of bone to treat.

2. Numbing

The skin and the outer layer of bone are numbed with local anesthetic.

3. Guided placement

Using X-ray or ultrasound guidance, a special needle is placed through the thin outer bone into the target area.

4. The treatment

The treatment, most often PRP made from your own blood, is injected into the bone. It is often combined with an injection into the joint. See PRP therapy in Fort Lauderdale.

The visit is done in the office, and you go home the same day. The area is often sore for a few days. Dr. Gonzalez gives you an activity and rehab plan. Read how image-guided injections improve accuracy.

What the Research Says About Intraosseous Injections

  • Early evidence: A review found only five studies, with 112 patients, on intraosseous PRP for knee arthritis. Patients improved in pain and function scores, and the most common side effect was pain at the injection site. The review found it was not yet clear whether adding the bone injection works better than a joint injection alone. Patel S, et al. Intraosseous Infiltration of Platelet-Rich Plasma for Knee Osteoarthritis: A Systematic Review of Literature and Limited Meta-analysis. Indian J Orthop. 2022;56(11):1847-1857. View the study.
  • Bone plus joint injection compared with joint injection alone: A study randomly split 50 people with moderate to severe knee arthritis into PRP in the joint only, or PRP in the joint plus the bone. Both groups improved. At 6 months, the difference in pain between the groups was not clear. Barman A, et al. Single intra-articular injection with or without intra-osseous injections of platelet-rich plasma in the treatment of osteoarthritis knee: A single-blind, randomized clinical trial. Injury. 2022;53(3):1247-1253. View the study.

Intraosseous Injections in Fort Lauderdale

Providing intraosseous and image-guided injections to residents in Fort Lauderdale, Plantation, Oakland Park, Tamarac, Pompano Beach, and Broward County, and to patients from across South Florida. For our Hialeah office, se habla español.

Institute of Regenerative Orthopedics & Sports Medicine (IROSM)
3333 West Commercial Blvd, Suite 101
Fort Lauderdale, FL 33309
Phone: (954) 751-6990

Frequently Asked Questions About Intraosseous Injections

What is an intraosseous injection?

What is an intraosseous injection?
An intraosseous (IO) injection places medicine or a treatment directly inside a bone. In emergencies it is used to give fluids when a vein cannot be found. In orthopedics, it is used to treat a painful area of bone, such as bone under the knee joint.

What is a bone injection used for in orthopedics?

What is a bone injection used for in orthopedics?
It may be considered for severe knee arthritis with bone swelling on MRI, slow-healing fractures, stress fractures and some early cases of osteonecrosis. Dr. Gonzalez decides case by case.

Is an intraosseous injection painful?

Is an intraosseous injection painful?
The skin and outer bone are numbed first. Most people feel pressure, and the area is often sore for a few days afterward.

What is injected into the bone?

What is injected into the bone?
At IROSM, it is most often PRP made from your own blood, sometimes combined with an injection into the joint.

Does an intraosseous injection work?

Does an intraosseous injection work?
Research is early. Studies show patients often improve, but it is not yet clear how much the bone injection adds to a joint injection alone. Results vary, and Dr. Gonzalez will explain whether it fits you.

Is an intraosseous injection covered by insurance?

Is an intraosseous injection covered by insurance?
Orthopedic intraosseous PRP is usually not covered by insurance. Our team explains the cost clearly before treatment.

Do I need a referral to be seen at IROSM?

Do I need a referral to be seen at IROSM?
It depends on your insurance. Many HMO, Medicare Advantage and Medicaid plans need a referral from your primary care doctor before you see a specialist. Please check with your plan, or call us at (954) 751-6990 before your visit to confirm.

Find Out if a Bone Injection Fits Your Problem

Triple board-certified · Fellowship-trained at the Andrews Institute · Fort Lauderdale & Hialeah

Schedule a consultation with Dr. Jorge Gonzalez at IROSM in Fort Lauderdale to review your MRI and learn whether an intraosseous injection is an option for you.

Book Your Appointment Now: (954) 751-6990 Make an Inquiry Online
Dr. Jorge A. Gonzalez, MD
Medically reviewed by: Dr. Jorge A. Gonzalez, MD
Institute: Institute of Regenerative Orthopedics & Sports Medicine (IROSM)
Last reviewed: September 2026

Disclaimer: This content is for general educational purposes and does not constitute formal medical advice. Individual patient outcomes will vary. Intraosseous injection treatment at IROSM in Fort Lauderdale requires a clinical examination by Dr. Jorge Gonzalez to establish candidacy. Serving Fort Lauderdale, Pompano Beach, Plantation, and surrounding Broward County communities.